6533b836fe1ef96bd12a1345
RESEARCH PRODUCT
Role of NF-kappaB in immune and inflammatory responses in the gut.
K BarbulescuChristoph BeckerMarkus F. Neurathsubject
InflammationMice KnockoutGastroenterologyNF-kappa BInflammationPromoterReviewBiologyNFKB1Proinflammatory cytokineIκBαIntestinal DiseasesMiceImmune systemProteasomeImmunologymedicineAnimalsHumansmedicine.symptomTranscription factorSignal TransductionTranscription Factorsdescription
NF-kappaB is a pleiotropic transcription factor with key functions in the intestinal immune system. NF-kappaB family members control transcriptional activity of various promoters of proinflammatory cytokines, cell surface receptors, transcription factors, and adhesion molecules that are involved in intestinal inflammation. The perpetuated activation of NF-kappaB in patients with active inflammatory bowel disease suggests that regulation of NF-kappaB activity is a very attractive target for therapeutic intervention. Such strategies include antioxidants, proteasome inhibitors, inhibition of NF-kappaB by adenoviral I kappaB alpha expression vectors, and antisense DNA targeting of NF-kappaB. These approaches will hopefully permit the design of new treatment strategies for chronic intestinal inflammation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-12-01 | Gut |