6533b836fe1ef96bd12a1431
RESEARCH PRODUCT
Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets.
Kamran ZaheerPeter Langguthsubject
Chemistry PharmaceuticalPharmaceutical ScienceLactose02 engineering and technology030226 pharmacology & pharmacyDosage formExcipients03 medical and health sciencesViscosity0302 clinical medicineDrug DiscoverySodium Starch GlycolateImmediate releaseDissolutionPharmacologyFOOD EFFECTChemistryViscosityOrganic Chemistryfood and beveragesPovidoneStarch021001 nanoscience & nanotechnologyBioavailabilityChemical engineeringSolubilityFoodCarboxymethylcellulose Sodium0210 nano-technologyFederal stateTabletsdescription
Food induced viscosity can delay disintegration and subsequent release of API from solid dosage form which may lead to severe reduction in the bioavailability of BCS type III compounds. Formulations of such tablets need to be optimized in view of this postprandial viscosity factor. In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state. Tablets containing these disintegrants were compressed at 10 and 30 KN, while taking lactose as a soluble filler. In addition to other compendial tests, disintegration force of these formulations was measured by texture analysis. Comparison of parameters derived from force - time curves revealed a direct relation of maximum disintegration force (F
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-10 | Drug development and industrial pharmacy |