6533b836fe1ef96bd12a1450
RESEARCH PRODUCT
An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity
Salvador GilMargarita ParraPablo Rodriguezsubject
BromoacetonitrileAcetonitrilesenediolateCarboxylic acidCarboxylic AcidsPharmaceutical Scienceregioselectivity.ArticleAnalytical Chemistrylcsh:QD241-441GABAlcsh:Organic chemistryDrug DiscoveryOrganic chemistryPhysical and Theoretical ChemistryAmino AcidsPhenylacetateschemistry.chemical_classificationOrganic Chemistryγ-aminoacidsRegioselectivityStereoisomerismCombinatorial chemistryAmideschemistryChemistry (miscellaneous)regioselectivityMolecular Medicineγ-aminoacidsbromoacetonitriledescription
Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding gamma-cyanoacids, which on hydrogenation yielded gamma-amino acids. This two step methodology improves upon previously described results. Poor e.e's resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amide induction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-03-27 | Molecules |