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RESEARCH PRODUCT
Catalytic Efficiency of a New Tridentate Ferrocenyl Phosphine Auxiliary: Sonogashira Cross-Coupling Reactions of Alkynes with Aryl Bromides and Chlorides at Low Catalyst Loadings of 10-1 to 10-4 mol %.
Maurice SantelliVladimir V. IvanovJean-cyrille HiersoHenri DoucetRégine AmardeilPhilippe MeunierAziz Fihrisubject
DenticityArylOrganic ChemistrySonogashira couplingHalideGeneral MedicineBiochemistryCoupling reactionCatalysischemistry.chemical_compoundchemistryPolymer chemistryOrganic chemistryPhysical and Theoretical ChemistryCatalytic efficiencyPhosphinedescription
[structure: see text] The catalytic activity in Sonogashira cross-coupling reactions of alkynes with a variety of aryl halides (including chlorides) using a multidentate ferrocenyl phosphine is presented. The novel mixed ferrocenyl aryl/alkyl triphosphine is thermally stable and insensitive to air or moisture, and its robustness allows aryl alkynylation at 10(-1) to 10(-4) mol % catalyst loadings with TONs up to 250,000. Copper-free coupling using phenylacetylene is also accessible in good yield.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-11 | ChemInform |