6533b836fe1ef96bd12a1615
RESEARCH PRODUCT
Beyond islet trasplantation in diabetes cell terapy:from embryonic stem cells to transdifferentation of adult cells
Maurizio BellaviaGiuseppe DamianoA.i. Lo MonteMaria Concetta Giovialesubject
AdultIslets of Langerhans TransplantationBiologyCell therapyTherapeutic approachIslet transplantationdiabetes embryonic stem cellstransdifferentationSettore BIO/13 - Biologia ApplicataDiabetes mellitusDiabetes MellitusmedicineHumansEmbryonic Stem CellsTransplantationgeographygeography.geographical_feature_categoryTransdifferentiationCell Differentiationmedicine.diseaseIsletEmbryonic stem cellTransplantationSettore MED/18 - Chirurgia GeneraleImmunologyCancer researchSurgeryPancreatic islet transplantationdescription
Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight regulation of glucose leading to long-term complications. Recently, pancreatic islet transplantation to reconstitute insulin-producing cells, has emerged as an alternative promising therapeutic approach. Unfortunately, the number of donor islets is too low compared with the high number of patients needing a transplantation leading to a search for renewable sources of high-quality -cells. This review, summarizes more recent promising approaches to the generation of new -cells from embryonic stem cells for transdifferentiation of adult cells, particularly a critical examination of the seminal work by Lumelsky et al.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |