6533b836fe1ef96bd12a1638

RESEARCH PRODUCT

Ion-exchange fibers and drugs: a transient study.

Marja VuorioJosé A. ManzanaresKyösti KontturiLasse MurtomäkiJouni HirvonenTarja Kankkunen

subject

Ion exchangeChemistryStereochemistryTextilesKineticsPharmaceutical Science02 engineering and technologyModels Theoretical021001 nanoscience & nanotechnology030226 pharmacology & pharmacyControlled releaseDosage formIon Exchange03 medical and health sciences0302 clinical medicineChemical engineeringPharmaceutical PreparationsDrug deliveryFiberIon Exchange Resins0210 nano-technologyIon-exchange resinEquilibrium constant

description

The objective of this study was to theoretically model and experimentally measure the kinetics and extent of drug release from different ion-exchange materials using an in-house-designed flow-cell. Ion-exchange fibers (staple fibers and fiber cloth) were compared with commercially available ion-exchange materials (resins and gels). The functional ion-exchange groups in all the materials were weak -COOH or strong -SO3H groups. The rate and extent of drug release from the fibers (staple fiber>fiber cloth) was much higher than that from the resin or the gel. An increase in the hydrophilicity of the model drugs resulted in markedly higher rates of drug release from the fibers (nadolol>metoprolol>propranolol>tacrine). Theoretical modelling of the kinetics of ion exchange provided satisfactory explanations for the experimental observations: firstly, a change in the equilibrium constant of the ion-exchange reaction depending on the drug and the ion-exchange material and, secondly, a decrease in the Peclet number (Pe) with decreasing flow-rate of the drug-releasing salt solution.

10.1016/s0168-3659(03)00270-0https://pubmed.ncbi.nlm.nih.gov/12932721