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RESEARCH PRODUCT

How important are satiation and satiety for weight regulation?

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Abstract: This chapter discusses how body weight is regulated in adult humans by a cybernetic-like process, whose main physiological response is the control of food intake, while energy expenditure modulation probably only passively participates in the adjustment of energy balance. The historical emergence and scientific definition of the two concepts ‘satiety’ and ‘satiation’ are recapitulated and their respective roles in body weight regulation are discussed. The original methodology developed to differentiate and separately quantify the roles of satiety and satiation in the quantitative control of food intake of healthy human subjects is described. Finally, the respective importance of satiety and satiation is presented in terms of long-term body weight regulation.