6533b836fe1ef96bd12a1c82
RESEARCH PRODUCT
Response to 'TH1 and TH2 cytokine control of thyrocyte survival in thyroid autoimmunity'
Giorgio StassiLuigi RucoRuggero De MariaAntonella Stoppacciarosubject
business.industrymedicine.medical_treatmentImmunologymedicine.diseaseDifferential effectsAutoimmune thyroiditisCytokineImmune systemImmunologyThyroid autoimmunitymedicineImmunology and AllergyTh1 cytokinesbusinessdescription
Mirakian et al. question our recent results, which suggest that thyrocyte survival during thyroid autoimmunity depends on differential effects of TH1 and TH2 cytokines1. Thyrocyte destruction in autoimmune thyroiditis is a slow process that lasts several years. We hypothesized that in thyroid autoimmunity the balance between life and death in thyrocytes depends on the predominance over the time of TH2 and TH1 cytokines, whose action is not restricted to immune cells but involves direct modulation of key molecules responsible for survival or death of target cells1.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-05-01 | Nature Immunology |