6533b837fe1ef96bd12a1d2f
RESEARCH PRODUCT
Effect of sulpiride in endogenous depression.
O. BenkertF. Holsboersubject
DrugAdultMalemedicine.medical_specialtyTime FactorsDosemedia_common.quotation_subjectEarly RelapsePharmacologyMaintenance therapymedicineHumansPsychiatryDepression (differential diagnoses)media_commonClinical Trials as TopicDepressive DisorderMiddle AgedPsychiatry and Mental healthEndogenous depressionAntidepressantFemaleSulpiridePsychologySulpiridemedicine.drugdescription
Clinical practice and pharmacological data suggest a possible antidepressive action of sulpiride given in low dosages. To further explore the therapeutic efficacy of sulpiride 11 patients with an endogenous type of depression were studied during treatment with an oral daily dose of 150 mg sulpiride. The present data allows the conclusion that (A) low dosed sulpiride seems to act as an antidepressant in severe and milder forms of depression, (B) a clinical progress is seen earlier than is common during treatment with tricyclics and (C) a significant increase of drive is observable. However, sulpiride maintenance therapy did not prevent early relapse into depression. The preliminary nature of these clinical observations does not allow conclusions about the ultimate utility of this drug. Moreover, it remains unclear for which patients sulpiride is appropriate or perhaps superior to conventional treatment modalities of depression.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1984-01-01 | Acta psychiatrica Scandinavica. Supplementum |