6533b837fe1ef96bd12a1d4a

RESEARCH PRODUCT

Age-related changes of NADPH-diaphorase-positive neurons in the rat inferior colliculus and auditory cortex

Daniel Sánchez-zuriagaNuria Martí-gutiérrezMaria Rosa Peris-sanchisMaria ÁNgeles Pérez De La Cruz

subject

Inferior colliculusAgingAuditory PathwaysHistologyAuditory areaCentral nervous systemBiologyNADPH diaphoraseNitric OxideAuditory cortexNitric oxidechemistry.chemical_compoundmedicineAnimalsRats WistarInstrumentationAuditory CortexNeuronsNADPH DehydrogenaseRatsNitric oxide synthaseMedical Laboratory Technologymedicine.anatomical_structurechemistryAgeingbiology.proteinAnatomyNeuroscience

description

Nitric oxide (NO) has been implied in age-related changes of the central nervous system (CNS) and the central auditory pathway. The present study was conducted to investigate whether the number of NO-producing cells and their morphometric characteristics in the inferior colliculus (IC) and the auditory cortex (AC) are changed with the increasing age of the subjects. IC and AC sections of adult and senile Wistar rats were studied using the histochemical detection of NADPH-diaphorase activity (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS). Our results showed a decreased area of the somas of NADPH-d-positive neurons in the dorsal cortex (DC) of the IC and a diffuse loss of NADPH-d-positive neurons in the senile IC and primary cortical auditory area (Te1). However, an increased number of NO-producing cells have been shown by other authors in different parts of the ageing auditory pathway and CNS. It seems that age-related changes in NADPH-d-positive cells may follow a region-specific route. These changes may be related to hearing impairments with increasing age. Microsc. Res. Tech., 2007. © 2007 Wiley-Liss, Inc.

yearjournalcountryeditionlanguage
2007-08-28Microscopy Research and Technique
https://doi.org/10.1002/jemt.20512