6533b837fe1ef96bd12a1e19
RESEARCH PRODUCT
Enantioselective addition of Et2Zn to seven‐membered cyclic imines catalyzed by a (R)-VAPOL-Zn(II) complex
Lode De MunckVerena SukowskiJosé R. PedroCarlos Vilasubject
chemistry.chemical_classificationAldimine010405 organic chemistryChemistryStereochemistryOrganic ChemistryEnantioselective synthesischemistry.chemical_elementZincAlkylation010402 general chemistry01 natural sciencesBiochemistry0104 chemical sciencesCatalysischemistry.chemical_compoundCatàlisiDrug DiscoveryOxazepineQuímica orgànicadescription
Various substituted dibenzo[b,f][1,4]oxazepines underwent an enantioselective alkylation with Et2Zn catalyzed by a (R)-VAPOL-Zn(II) complex. The corresponding chiral 11-ethyl-10,11-dihydrodibenzo[b,f][1,4]oxazepine derivatives were obtained with good yields and moderate enantioselectivities. This represents the first example of enantioselective addition of Et2Zn to cyclic aldimines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-01 | Tetrahedron Letters |