Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes

6533b837fe1ef96bd12a1e3c

RESEARCH PRODUCT

Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes

Michel Kendy Souza Rosangela Vieira Andrade Rodrigo Vanerson Passos Neves Milton Rocha Moraes Marko Korhonen Herbert Gustavo Simões Erica Carine Campos Caldas Rosa Thiago Santos Rosa Caio Victor Sousa Samuel Da Silva Aguiar Lysleine Alves Deus

subject

Adult Male 0301 basic medicine Aging Cancer Research medicine.medical_specialty Physiology medicine.medical_treatment Clinical Biochemistry Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry Running Young Adult 03 medical and health sciences 0302 clinical medicine Biomarkers of aging Endurance training Internal medicine Humans Medicine Klotho Aged Inflammation biology Athletes business.industry Middle Aged biology.organism_classification Endurance Training Fibroblast Growth Factor-23 Cross-Sectional Studies 030104 developmental biology Endocrinology Cytokine Sprint Athletes medicine.symptom business Oxidation-Reduction Biomarkers Oxidative stress

description

Purpose: Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls. Methods: Participants were male master sprinters (SA, 50±8.9yrs; n=13) and endurance runners (EA, 53±8.2yrs; n=18) with remarkable athletic experience (∼25yrs of practice), besides untrained young (YC, 22.7±3.9yrs; n=17) and age-matched controls (MC, 45.5±9.8yrs; n=12). Anamnesis, anthropometrics, biomarkers of aging, inflammation status and oxidative stress parameters were analyzed in all participants. Results: An increased pro-oxidant activity (elevated protein carbonyl; isoprostanes and 8-OHdG) was observed for MC in comparison to remaining groups (p<0.05). However, SA presented a better antioxidant capacity than both MC and EA, while nitrite/nitrate (NOx) availability was higher for EA and lower for the MC (p<0.05). Both groups of athletes presented a better anti-inflammatory status than MC (increased IL-10 and lowered IL-6, sIL-6R, sTNF-RI), but worse than YC (increased TNF-α, sTNF-RI, and sIL-6R) (p<0.05). Telomere length was shorter in MC, which also had lower levels of irisin and klotho, and elevated FGF-23 (p<0.05). ADMA levels were higher in MC and SA, while irisin was lower in EA when compared to SA and YC (p<0.05). Conclusion: Master athletes presented better redox balance and inflammatory status, with decreased biomarkers of aging compared to control. Regarding exercise mode, a better NO- profile, as a marker of endothelial function, was observed for EA, whereas SA had a better redox balance, cytokines profile and attenuated biomarkers of aging.

year	journal	country	edition	language
2019-10-17	Nitric Oxide

https://doi.org/10.1016/j.niox.2020.05.004