6533b837fe1ef96bd12a1f0f
RESEARCH PRODUCT
Fructose 2,6-bisphosphate as a signal for changing from sugar to lipid oxidation during flight in locusts
Eric A. NewsholmeRomi MichelGerhard Wegenersubject
animal structures6-phosphofructokinaseBiophysicsBiochemistrychemistry.chemical_compoundLipid oxidationStructural BiologyGeneticsGlycolysis(Locust flight muscle)SugarMolecular BiologyFructose 2biologyActivator (genetics)FructoseCell BiologyFat oxidationCarbohydratebiology.organism_classificationchemistryBiochemistryFructose 26-bisphosphate6-bisphosphateGlycolysisInsect migrationLocustdescription
AbstractFlight in locusts is initially powered mainly by carbohydrate but if flight is to be sustained, as in migration, the animals have to utilize fat as the predominant fuel. The molecular basis of this metabolic switch has not been identified. Fructose 2,6-bisphosphate is a potent activator of 6-phosphofructokinase (EC 2.7.1.11) purified from locust flight muscle. After the first few minutes of flight in the locust the concentration of fructose 2,6-bisphosphate in the flight muscle falls dramatically, which should lead to a decrease in the activity of 6-phosphofructokinase as part of the mechanism to conserve carbohydrate during prolonged flight.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-05-26 | FEBS Letters |