Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

6533b837fe1ef96bd12a1f76

RESEARCH PRODUCT

Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

Antoine Yrondi Guillaume Vaiva Michel Walter Thierry D Amato Frank Bellivier Djamila Bennabi Thierry Bougerol Vincent Camus Olivier Doumy Jean-baptiste Genty Emmanuel Haffen Jérôme Holtzmann Mathilde Horn Christophe Lançon Marion Leboyer Pierre-michel Llorca Julia Maruani Rémi Moirand Fanny Molière Jean Petrucci Raphaelle Richieri Ludovic Samalin Laurent Schmitt Florian Stephan Philippe Courtet Wissam El-hage Bruno Aouizerate B. Aouizerate D. Bennabi M. Leboyer E. Haffen P.m. Llorca V. Barteau S. Bensalem H. Laouamri Karmene Souryis L. Mallet L. Yon J. Petrucci J.b. Genty A. Yrondi D. Pierre L. Schmitt M. Sarrail E. Haffen Djamila Bennabi I. Ryff E. Beuchet G. Tio C. Cappe E. Clerc P.m. Llorca M. Garnier R.m. Honciuc E. Allauze O. Blanc F. Bellivier N. Allaili I. Nieto J. Meheust Y. Sunthavy J. Maruani T. Bougerol M. Polosan P. Courvoisier J. Holtzmann B. Fredembach S. Foubert-andreani V. Camus W. El Hage T. D’amato F. Haesebaert C. Dubien M. Lefebvre A. Meznad J. Brunelin R. Moirand B. Aouizerate O. Doumy C. Lancon R. Richieri P. Peri M. Faugere C. Faget-agius P. Courtet J.p. Boulenger F. Moliere F. Stephan M. Walter C. Mesmeur G. Vaiva M. Horn

subject

Depressive disorders MESH: Depression MESH: Violence Population Poison control Violence Suicide prevention Childhood trauma MESH: Depressive Disorder Treatment-Resistant Suicidal Ideation Depressive Disorder Treatment-Resistant 03 medical and health sciences 0302 clinical medicine MESH: Risk Factors Risk Factors Rating scale Surveys and Questionnaires Humans Medicine MESH: Surveys and Questionnaires Risk factor education Suicidal ideation Childhood neglect Biological Psychiatry education.field_of_study MESH: Humans MESH: Suicidal Ideation Depression business.industry Childhood abuse CTQ tree 3. Good health 030227 psychiatry Suicide Psychiatry and Mental health [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Treatment-resistant depression medicine.symptom Columbia Suicide Severity Rating Scale business 030217 neurology & neurosurgery Clinical psychology

description

International audience; Objective: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations.Methods: Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively.Results: Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect: β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores.Conclusion: We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population.

year	journal	country	edition	language
2021-03-01

10.1016/j.jpsychires.2020.12.055 http://hdl.handle.net/20.500.12278/112823