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RESEARCH PRODUCT
ChemInform Abstract: A Straightforward Copper-Free Palladium Methodology for the Selective Alkynylation of a Wide Variety of S-, O-, and N-Based Mono- and Diheterocyclic Bromides and Chlorides.
Philippe MeunierSamer SalehMichel PicquetJean-cyrille Hiersosubject
Pyridazinechemistry.chemical_compoundchemistryBenzothiazolePyrazineIonic liquidQuinolineThiophenechemistry.chemical_elementOrganic chemistryGeneral MedicineThiazolePalladiumdescription
Abstract High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position -2, -3 or -5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1 mol % palladium only, with inexpensive PPh3 and amine base. The ionic liquid solvent allows a straigtforward separation of products and recycling opportunity. Unsuitable substrates and secondary reactions are also reported in order to point out further progress in cross-coupling using ionic liquids.
year | journal | country | edition | language |
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2009-12-29 | ChemInform |