Search results for "Pyrazine"
showing 10 items of 325 documents
CCDC 671674: Experimental Crystal Structure Determination
2011
Related Article: S.Shit, S.K.Dey, C.Rizzoli, E.Zangrando, G.Pilet, C.J.Gomez-Garcia, S.Mitra|2011|Inorg.Chim.Acta|370|18|doi:10.1016/j.ica.2011.01.008
CCDC 164934: Experimental Crystal Structure Determination
2001
Related Article: H.Grove, J.Sletten, M.Julve, F.Lloret|2001|J.Chem.Soc.,Dalton Trans.||2487|doi:10.1039/b103588f
CCDC 247407: Experimental Crystal Structure Determination
2005
Related Article: J.Carranza, J.Sletten, C.Brennan, F.Lloret, J.Cano, M.Julve|2004|Dalton Trans.||3997|doi:10.1039/b412034p
CCDC 685749: Experimental Crystal Structure Determination
2009
Related Article: P.Gomez-Saiz, R.Gil-Garcia, M.A.Maestro, J.L.Pizarro, M.I.Arriortua, L.Lezama, T.Rojo, M.Gonzalez-Alvarez, J.Borras, J.Garcia-Tojal|2008|J.Inorg.Biochem.|102|1910|doi:10.1016/j.jinorgbio.2008.06.015
A Combined Experimental and Theoretical Study of the Ammonium Bifluoride Catalyzed Regioselective Synthesis of Quinoxalines and Pyrido[2,3-b]pyrazines
2015
International audience; Ammonium bifluoride was efficiently used (at a 0.5 mol % loading) to catalyze the cyclocondensation between 1,2-arylenediamines and 1,2-dicarbonyl compounds at room temperature in methanol-water, affording quinoxalines and pyrido[2,3-b]pyrazines in excellent yields. Importantly, 2,8-disubstituted quinoxalines and 3-substituted pyrido[2,3-b]pyrazines were regioselectively formed by reacting aryl glyoxals with 3-methyl-1,2-phenylenediamine and 2,3-diaminopyridine, respectively. Analysis of the DFT reactivity indices allowed to explain the catalytic role of ammonium bifluoride.
How to fight multiple enemies : target-specific chemical defences in an aposematic moth
2017
Animals have evolved different defensive strategies to survive predation, among which chemical defences are particularly widespread and diverse. Here we investigate the function of chemical defence diversity, hypothesizing that such diversity has evolved as a response to multiple enemies. The aposematic wood tiger moth (Arctia plantaginis) displays conspicuous hindwing coloration and secretes distinct defensive fluids from its thoracic glands and abdomen. We presented the two defensive fluids from laboratory-reared moths to two biologically relevant predators, birds and ants, and measured their reaction in controlled bioassays (no information on colour was provided). We found that defensive…
Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein.
2017
The association between hypertension and an increased risk for Alzheimer's disease (AD) and dementia is well established. Many data suggest that modulation of the renin-angiotensin system may be meaningful for the prevention and therapy of neurodegenerative disorders, in particular AD. Proteolytic cleavage of the amyloid precursor protein (APP) by α-secretase precludes formation of neurotoxic Aβ peptides and is expected to counteract the development of AD. An established approach for the up-regulation of α-secretase cleavage is the activation of G protein-coupled receptors (GPCRs). Therefore, our study aimed to analyze whether stimulation of angiotensin AT1 or AT2 receptors stably expressed…
Synthesis of Novel Polyazinyl-Substituted Triazolopyridines from [1,2,3]Triazolo[1,5-a]pyridines
2017
A series of 7-azinyl-substituted triazolopyridines and 3-(6-azinyl-substituted 2-pyridyl)triazolopyridines were synthesized by addition of the corresponding 3-substituted 7-lithiotriazolopyridine to pyrimidine, pyrazine, pyridazine, and 1,3,5-triazine respectively, followed by hydrolysis and oxidation.
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
2017
ObjectiveCancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.DesignTo discover potential therapeutics to be clinically investigated as single agent, we performed a screening with a panel of FDA-approved or investigational drugs on primary CRC cells enriched for CSCs (CRC-SCs) isolated from 27 patients. Candidate predictive biomarkers of efficacy were identified by integrating genomic, reverse-phase protein mic…
CCDC 1575617: Experimental Crystal Structure Determination
2017
Related Article: Matthew M. Morgan, Evan A. Patrick, J. Mikko Rautiainen, Heikki M. Tuononen, Warren E. Piers, Denis M. Spasyuk|2017|Organometallics|36|2541|doi:10.1021/acs.organomet.7b00051