6533b837fe1ef96bd12a265a

RESEARCH PRODUCT

ChemInform Abstract: Carbohydrate Nanocarriers in Biomedical Applications: Functionalization and Construction

Frederik R. WurmKatharina LandfesterTill OpatzBiao Kang

subject

chemistry.chemical_classificationBiocompatibilitychemistryBiomoleculeTherapeutic treatmentSurface modificationNanotechnologyTumor cellsGeneral MedicineNanocarriers

description

The specific targeting of either tumor cells or immune cells in vivo by carefully designed and appropriately surface-functionalized nanocarriers may become an effective therapeutic treatment for a variety of diseases. Carbohydrates, which are prominent biomolecules, have shown their outstanding ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The recent applications of sugar (mono/oligosaccharides and/or polysaccharides) for the development of nanomedicines are summarized in this review, including the application of carbohydrates for the surface-functionalization of various nanocarriers and for the construction of the nanocarrier itself. Current problems and challenges are also addressed.

yearjournalcountryeditionlanguage
2015-12-01ChemInform
https://doi.org/10.1002/chin.201551236