ChemInform Abstract: Modular One-Pot Synthesis of Tetrasubstituted Pyrroles from α-(Alkylideneamino)nitriles.

6533b837fe1ef96bd12a268f

RESEARCH PRODUCT

ChemInform Abstract: Modular One-Pot Synthesis of Tetrasubstituted Pyrroles from α-(Alkylideneamino)nitriles.

subject

chemistry.chemical_compound chemistry One-pot synthesis Organic chemistry Regioselectivity Nitroalkane General Medicine Ring (chemistry)Combinatorial chemistry Cycloaddition Pyrrole derivatives Pyrrole

description

2,3,4,5-Tetrasubstituted pyrroles have been prepared with high regioselectivity by a formal cycloaddition of α-(alkylideneamino)nitriles and nitroolefins followed by elimination of HCN and HNO2. The reaction allows the convergent construction of the pyrrole ring in four steps from a nitroalkane and three aldehydes.

year	journal	country	edition	language
2008-01-29	ChemInform

https://doi.org/10.1002/chin.200805107

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