6533b837fe1ef96bd12a2791
RESEARCH PRODUCT
Persistence of Nonceliac Wheat Sensitivity, Based on Long-term Follow-up
Ada Maria FlorenaGiuseppe IaconoFrancesca FayerAntonio CarroccioA. AriniFrancesco La BlascaFrancesca CavataioGirolamo GeraciAlberto D'alcamoPasquale MansuetoMaurizio SoresiRosario Iacobuccisubject
AdultMalemedicine.medical_specialtyPathologySettore MED/09 - Medicina InternaLong term follow upNonceliac Wheat SensitivityWheat HypersensitivityPersistence (computer science)PersistenceDiet Gluten-Free03 medical and health sciences0302 clinical medicineFood allergySurveys and QuestionnairesInternal medicinemedicineHumansProspective StudiesIrritable bowel syndromeHepatologyLong-term Follow-upbusiness.industryGastroenterologyMiddle Agedmedicine.disease030220 oncology & carcinogenesisChronic DiseasePatient CompliancePersistence; Nonceliac Wheat Sensitivity; Long-term Follow-upFemale030211 gastroenterology & hepatologySymptom AssessmentbusinessFollow-Up Studiesdescription
We investigated how many patients with a diagnosis of nonceliac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy; 148 of these individuals were still on a strict wheat- free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared with 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P < .0001). Of the 22 patients who repeated the double-blind, placebo- controlled challenge, 20 reacted to wheat. We conclude that NCWS is a persistent condition. Clinicaltrials.gov registration number: NCT02823522.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |