6533b837fe1ef96bd12a27e6
RESEARCH PRODUCT
Calixarene: A Versatile Material for Drug Design and Applications
Gulzar MuhammadMuhammad Ajaz HussainSyed Nasir Abbas BukhariMuhammad AshrafMuhammad Nawaz Tahirsubject
Drugmedia_common.quotation_subjectAnti-Inflammatory AgentsSupramolecular chemistrymacromolecular substances010402 general chemistry01 natural sciencesAnti-Infective AgentsDrug DiscoveryCalixareneHumansOrganic chemistryProdrugsAntihypertensive AgentsTargeted releasemedia_commonAnthelminticsPharmacologyDrug Carriers010405 organic chemistryChemistryProdrugBiocompatible material0104 chemical sciencesDrug DesignDrug releaseAnticonvulsantsCalixarenesAntipsychotic Agentsdescription
The therapy of various diseases by the drugs entrapped in calixarene derivatives is gaining attraction of researchers nowadays. Calixarenes are macrocyclic nano-baskets which belong to cavitands class of host-guest chemistry. They are the marvelous hosts with distinct hydrophobic three dimensional cavities to entrap and encapsulate biologically active guest drugs. Calixarene and its derivatives develop inclusion complexes with various types of drugs and vitamins for their sustained/targeted release. Calixarene and its derivatives are used as carriers for anti-cancer, anti-convulsant, anti-hypertensive, anthelmentic, anti-inflammatory, antimicrobial and antipsychotic drugs. They are the important biocompatible receptors to improve solubility, chemical reactivity and decrease cytotoxicity of poorly soluble drugs in supramolecular chemistry. This review focuses on the calixarene and its derivatives as the state-of-the-art in host-guest interactions for important drugs. We have also critically evaluated calixarenes for the development of prodrugs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-03-20 | Current Pharmaceutical Design |