6533b837fe1ef96bd12a2829
RESEARCH PRODUCT
Synthetic Approaches to Anti-Inflammatory Macrolactones of the Oxacyclododecindione Type
Markus RohrKristina RudolphJohannes TauberTill OpatzGerhard Erkelsubject
chemistry.chemical_classificationDouble bondStereochemistrymedicine.drug_classOrganic ChemistryHydroacylationTotal synthesisMetathesisRing (chemistry)Anti-inflammatoryRing-closing metathesischemistrymedicinePhysical and Theoretical ChemistryIsomerizationdescription
Various synthetic approaches to the oxacyclododecindione-type macrolactones, known for their potent anti-inflammatory activity, are presented. These include an attempted carbonylative ring closure, a hydroacylation route, and an approach by ring-closing metathesis and double bond isomerization, as well as a strategy including ring-closing metathesis/unsaturation. The last route allowed the preparation of a bioactive analogue of the recently described 14-deoxyoxacyclododecindione.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-07-24 | European Journal of Organic Chemistry |