6533b837fe1ef96bd12a30c9
RESEARCH PRODUCT
An efficient probe for sensing different concentration ranges of glutathione based on AIE-active Schiff base nanoaggregates with distinct reaction mechanism
Lingyun WangDerong CaoSimei WuHerbert MeierHao Tangsubject
Reaction mechanismanimal structures02 engineering and technology010402 general chemistryPhotochemistry01 natural sciencesThiol groupchemistry.chemical_compoundHydrolysisMaterials ChemistryElectrical and Electronic EngineeringInstrumentationchemistry.chemical_classificationHigh concentrationAddition reactionSchiff baseMetals and AlloysGlutathione021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistryThiol0210 nano-technologydescription
Abstract A novel tetraphenylethene-diketopyrrolopyrrole Schiff base (TPE-DPP) was synthesized by one-pot protocol. Based on thiol group and acid-base property of glutathione, nanoaggregates of TPE-DPP for sensitive and selective detection of diff ;erent concentration ranges of glutathione by two distinct reaction mechanisms was reported. It showed a turn-on mode of fluorescence signals towards low concentration of GSH by hydrolysis of TPE-DPP, but a ratiometric mode of fluorescence signal was elicited towards high concentration of GSH by addition reaction of thiol with TPE-DPP. What’s more, the probe was successfully utilized for monitoring GSH in living cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-01 | Sensors and Actuators B: Chemical |