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RESEARCH PRODUCT
O046. Color vision and visual cortex excitability are impaired in episodic migraine. Simply coexisting or pathophysiologically related dysfunctions?
Filippo BrighinaVittoria CalabróFabio LombardoRoberta BaschiGiuseppe VallarSimona MaccoraViviana FirpoNadia BologniniGiuseppe CosentinoBrigida Fierrosubject
medicine.medical_specialtyNeurologygenetic structuresAuraColor visionmedicine.medical_treatmentmedia_common.quotation_subjectIllusionClinical NeurologyAudiologymedicinemedia_commonTranscranial direct-current stimulationbusiness.industryGeneral Medicinemedicine.diseaseMigraine with auraMigraine Color Vision Migraine Patient Migraine With Aura. Migraine Without AuraAnesthesiology and Pain Medicine; Neurology (clinical)Visual cortexmedicine.anatomical_structureAnesthesiology and Pain MedicineMigraineOral PresentationNeurology (clinical)medicine.symptombusinessNeurosciencedescription
Background and objectives Evidence of abnormal color vision processing in migraine comes from observation of positive symptoms during visual aura, effects of strong color contrast triggering attacks and of colored-spectacles reducing migraine frequency. Although the central or peripheral basis of such color misperception remains unclear, several authors reported a selective deficit of shortwavelength cones (S-cones) [1]. Sound-induced flash illusions (SIFI) are a simple way to describe visual distorsion induced by acoustic perception. SIFI critically depend on excitability of primary visual cortex (V1) as they are reduced by facilitatory anodal transcranial direct current stimulation (tDCS) over V1 in healthy subjects [2]. We observed diminished SIFI in episodic migraine patients, especially in those with aura (MA) and during the attack [3] in agreement with the hypothesis of visual cortex hyperexcitability. Aim of the present study was to explore the potential correlation between cones dysfunction (evaluated by colorimetric scales) and visual cortex hyperexcitability (tested by SIFI) in episodic migraine without aura patients (MoA). Materials and methods Twenty-two MoA patients (4 M; mean age 35.8±11.1 years) and 12 unimpaired healthy volunteers with no family history of migraine (9 M; mean age 27.7±13.2 years) were enrolled. Migraine patients were tested interictally. None of the patients enrolled had taken any prophylactic drug during the 3 months prior to the
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | The Journal of Headache and Pain |