6533b837fe1ef96bd12a3180

RESEARCH PRODUCT

The burden of hepatocellular carcinoma in non-alcoholic fatty liver disease: Screening issue and future perspectives

Salvatore PettaFederica SpatolaCiro CelsaGrazia PennisiAntonina Giammanco

subject

OncologyHepatocellular carcinomaDiseaseReviewlcsh:ChemistryLiver disease0302 clinical medicineDisease ScreeningRisk FactorsMass ScreeningHCClcsh:QH301-705.5SpectroscopyFatty liverLiver NeoplasmsGeneral MedicineComputer Science Applications030220 oncology & carcinogenesisHepatocellular carcinoma030211 gastroenterology & hepatologyMiRNAmedicine.medical_specialtyMicro RNACarcinoma HepatocellularSingle-nucleotide polymorphismCatalysisTM6SF2Inorganic ChemistryDiabetes Complications03 medical and health sciencesDiabetes mellitusInternal medicineNAFLDmedicineAnimalsHumansObesityPhysical and Theoretical ChemistryMolecular BiologyPNPLA3Long non-conding RNAbusiness.industryOrganic Chemistrymedicine.diseasedigestive system diseasesLncRNAlcsh:Biology (General)lcsh:QD1-999businessTM6SF2Non-alcoholic fatty liver disease

description

In recent decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the Western world, and the occurrence of its complications, such as hepatocellular carcinoma (HCC), has rapidly increased. Obesity and diabetes are considered not only the main triggers for the development of the disease, but also two independent risk factors for HCC. Single nucleotide polymorphisms (such as PNPLA3, TM6SF2 and MBOAT7) are related to the susceptibility to the development of HCC and its progression. Therefore, an appropriate follow-up of these patients is needed for the early diagnosis and treatment of HCC. To date, international guidelines recommend the use of ultrasonography with or without alpha-fetoprotein (AFP) in patients with advanced fibrosis. Furthermore, the use of non-invasive tools could represent a strategy to implement surveillance performance. In this review, we analyzed the main risk factors of NAFLD-related HCC, the validated screening methods and the future perspectives.

yearjournalcountryeditionlanguage
2019-11-01
10.3390/ijms20225613http://hdl.handle.net/10447/387180