6533b837fe1ef96bd12a31c5
RESEARCH PRODUCT
Seizure following the Use of the COX-2 Inhibitor Etoricoxib
Valentina ArnaoMarianna RioloPaolo AridonBrigida Fierrosubject
medicine.diagnostic_testbusiness.industryCase Report030204 cardiovascular system & hematologyElectroencephalographylcsh:RC346-429Discontinuation03 medical and health sciences0302 clinical medicineText miningNeuroimagingAnesthesiaMedicineCOX-2 inhibitorCOX-2 inhibitorGeneral Agricultural and Biological SciencesbusinessEtoricoxib030217 neurology & neurosurgerylcsh:Neurology. Diseases of the nervous systemmedicine.drugdescription
We describe a case of epileptic seizures occurring after the use of a COX-2 inhibitor. A 61-year-old man was admitted to our department because of a generalized tonic-clonic seizure. EEG showed generalized slowdown of the activity. Neuroimaging and blood samples studies did not evidence alterations, but a careful pharmacological history revealed that the patient had taken the COX-2 inhibitor etoricoxib to treat lumbago few days before the onset of clinical symptoms. No seizures were reported after etoricoxib discontinuation and an EEG resulted to be normal two months after this. Conclusion. Knowing the pharmacological history of a patient is important for understanding the clinical presentation and selecting appropriate treatment. This is, to the best of our knowledge, the first reported case of generalized seizures associated with the use of COX-2 inhibitors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | Case Reports in Neurological Medicine |