Etoposide Treatment in Recurrent Medulloblastoma

6533b837fe1ef96bd12a3332

RESEARCH PRODUCT

Etoposide Treatment in Recurrent Medulloblastoma

P Gutjahr R. Boor A Huber

subject

Adult Male medicine.medical_specialty medicine.medical_treatment Neutropenia Gastroenterology Recurrence Prednisone Internal medicine medicine Humans Spinal Cord Neoplasms Neoplasm Metastasis Child Etoposide Etoposide Medulloblastoma Chemotherapy Brain Neoplasms business.industry General Medicine Recurrent Medulloblastoma Prognosis medicine.disease Frontal Lobe Surgery Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Toxicity Female Methotrexate Neurology (clinical)Tomography X-Ray Computed business Medulloblastoma medicine.drug

description

Five consecutive patients with recurrent medulloblastoma received etoposide 120 mg/m2 for 5 to 7 days at 2 to 4-week intervals. Three patients with neuroaxis dissemination received additional intrathecal chemotherapy with methotrexate, cytosine arabinoside and prednisone. Toxicity consisted of alopecia and mild neutropenia. Complete response was registered in two patients, partial response in one. Median survival was 19 months with the 3 responders living 6, 30 and 60+ months. Etoposide seems to be an active agent in medulloblastoma.

year	journal	country	edition	language
1994-02-01	Neuropediatrics

https://doi.org/10.1055/s-2008-1071580

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