6533b837fe1ef96bd12a33c1

RESEARCH PRODUCT

Biologic relevance of elevated red cell adenosine deaminase activity in myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria.

L. TedescoP. Di MarcoM. Tambone-reyesS. LunaP. CitarellaD. Tinnirello

subject

AdultMaleCancer Researchmedicine.medical_specialtyErythrocytesAdenosine DeaminaseHemoglobinuria Paroxysmal030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineAdenosine deaminaseInternal medicineFetal hemoglobinmedicineHumansPreleukemiaAgedRed Cellbiologybusiness.industryMyelodysplastic syndromeshemic and immune systemsGeneral MedicineMiddle Agedmedicine.diseaseEndocrinologyOncologyDysplasia030220 oncology & carcinogenesisMyelodysplastic Syndromesbiology.proteinParoxysmal nocturnal hemoglobinuriaElevated red cell adenosine deaminase activityFemaleHemoglobinbusiness

description

Red cell adenosine deaminase (ADA-RBC) activity in patients with myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria is significantly increased compared to that observed in normal controls. ADA-RBC activity is not related to fetal hemoglobin concentration, but it is significantly correlated with hemoglobin concentration at diagnosis and with the degree of morphologic dysplasia in the erythroid lineage. The results of our study suggest that the observed enzymatic abnormality may constitute a non-specific manifestation of the stem cell alteration that determines these disorders.

yearjournalcountryeditionlanguage
1992-12-31Tumori
10.1177/030089169207800604https://pubmed.ncbi.nlm.nih.gov/1297230