6533b837fe1ef96bd12a33cc

RESEARCH PRODUCT

Toxicity of 5- chloro- 3- methyl- catechol to rat: Chemical observations and light microscopy of the tissue

Marja Liisa HattuiaRaimo KreesAntti U. ArstilaHilkka ReunanenJuha Knuutinen

subject

MaleMicroscopyCatecholMethyl CatecholbiologyHealth Toxicology and MutagenesisMetaboliteCatecholsGeneral MedicineToxicologybiology.organism_classificationPollutionMCPAQuantitative determinationRatsLethal Dose 50Residue (chemistry)chemistry.chemical_compoundchemistryBiochemistryToxicityAnimalsBacteria

description

5-chloro-3-methyl-catechol was first time described by GAUNT and EVANS (1961) as a metabolite of MCPA (4-chloro-2-methylphenoxyacetic aci~which is the most widely used herbicide in the Nordic countries. The toxicity of the metabolite 5-chloro-3-methylcatechol bas hot been studied so far. Other catechols like 3,5dichlorocatechol has been shown to be a metabollte of 2,4-D (BOLLAG et ai. 1968a, BOLLAG et ai. 1968b), and it has been proven to be toxic to cells by HORVATH (1971). The catechols are metabolized by bacteria finally to muconic semialdehyde (HORVATH 1970, HORVATH and ALEXANDER 1970). In this work the toxicity of 5-chloro-3-methyl-catechol to maie rats was studied in acute and subchronic experiment in order to relate the histopathological changes in the tissues to the residue levels in the same tissues. A TLC method recently developed by SATTAR et ai. (1977) was used in the clean-up and the quantitative determination of the catechol residues occurred by glass capillary GLC.

yearjournalcountryeditionlanguage
1979-07-01Bulletin of Environmental Contamination and Toxicology
https://doi.org/10.1007/bf02026970