6533b837fe1ef96bd12a3449

RESEARCH PRODUCT

Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment

Gianluca GiavaresiCarla GentileEufrosina DimarcoLavinia RaimondiAngela De LucaValeria CarinaFabio CaradonnaViviana CostaMilena FiniDaniele Bellavia

subject

Endocrinology Diabetes and MetabolismOsteoporosisOsteoclasts030209 endocrinology & metabolismBioinformaticsBone resorption03 medical and health sciences0302 clinical medicineEndocrinologyOsteoclastSettore BIO/13 - Biologia ApplicataSettore BIO/10 - BiochimicaOsteoporosis treatmentbone erosive diseasesMedicineAnimalsHumansEpigeneticsProgressive osteopeniaOsteoblastsbusiness.industrySettore BIO/16 - Anatomia UmanaOsteoblastmedicine.diseaseosteoporosisSettore BIO/18 - Geneticamedicine.anatomical_structureflavonoidsosteoclastosteoblastbusinessHomeostasisepigenetic

description

Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP).

yearjournalcountryeditionlanguage
2020-08-05
10.1016/j.tem.2020.11.007http://hdl.handle.net/10447/454018