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RESEARCH PRODUCT

Bifunctional Acid-Base Catalysis

Hasibur RahamanPetri M. Pihko

subject

inorganic chemicalschemistry.chemical_compoundchemistryHydrogen bondTetrahedral carbonyl addition compoundOxyanion holeBifunctionalCombinatorial chemistryFrustrated Lewis pairBifunctional catalystCatalysisEnzyme catalysis

description

Acid-base catalysis with bifunctional catalysts is a very prominent catalytic strategy in both small-molecule organocatalysts as well as enzyme catalysis. In both worlds, small-molecule catalysts and enzymatic catalysis, a variety of different general acids or hydrogen bond donors are used. In this chapter, important parallels between small molecule catalysts and enzymes are discussed, and a comparison is also made to the emerging field of frustrated Lewis pair catalysis.

yearjournalcountryeditionlanguage
2011-01-01
https://doi.org/10.1007/978-90-481-3865-4_6