6533b838fe1ef96bd12a3b79
RESEARCH PRODUCT
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subject
ChromatographyChemistryPharmaceutical ScienceCapsule02 engineering and technology021001 nanoscience & nanotechnologyPositive correlation030226 pharmacology & pharmacySmall intestineDosage formIn vitro03 medical and health sciences0302 clinical medicinemedicine.anatomical_structuremedicineDissolution testingImmediate release0210 nano-technologyDissolutiondescription
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for disintegration (in a compendial disintegration tester) and for dissolution in both USP type I (basket) and type II (paddle) apparatuses using different media. Overall, good correlations were obtained. This was observed for both the basket and the paddle apparatus, indicating that the use of disintegration testing as a surrogate for dissolution testing (allowed by International Conference on Harmonization (ICH) for immediate release dosage forms in case, in addition to other conditions, a correlation between disintegration and dissolution is proven) could be extended to include delayed release dosage forms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-03 | Pharmaceutics |