6533b838fe1ef96bd12a3cb3

RESEARCH PRODUCT

Synthesis and Antileukemic Activity of New 3-(5-Methylisoxazol-3-yl) and 3-(Pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.

Benedetta MaggioFabiana PlesciaStella CascioferroDomenico SchillaciGiuseppe DaidoneDemetrio Raffa

subject

Human leukemiaStereochemistryDrug Evaluation PreclinicalPharmaceutical ScienceAntineoplastic AgentsHL-60 Cells3-(3-Methylisoxazol-5-yl)-2-styrylquinazolin-4(3H)-ones 3-(Pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones Antileukemic activitySettore BIO/19 - Microbiologia GeneraleAcetic acidchemistry.chemical_compoundDrug DiscoverymedicineColchicineAnimalsHumansLeukemia L1210OxazolesCzech RepublicMolecular StructureChemistryGeneral Medicinemedicine.diseaseSettore CHIM/08 - Chimica FarmaceuticaIn vitroLeukemiaCell cultureQuinazolinesColchicineK562 CellsBenzoic AldehydeK562 cellsChronic myelogenous leukemia

description

3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

yearjournalcountryeditionlanguage
2003-08-13ChemInform
https://doi.org/10.1002/chin.200444180