Modifications in the production of cytokines and growth factors in drainage fluids following mesh implantation after incisional hernia repair

6533b838fe1ef96bd12a3cf5

RESEARCH PRODUCT

Modifications in the production of cytokines and growth factors in drainage fluids following mesh implantation after incisional hernia repair

Pietro D'agostino Gaetano Di Vita Mariangela Angileri Matteo Arcara Giuseppe Caruso Rosalia Patti Enrico Cillari Viviana Ferlazzo Gianluca Sieli Salvatore Buscemi

subject

Adult Vascular Endothelial Growth Factor A medicine.medical_specialty incisional hernia Incisional hernia medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Polypropylenes chemistry.chemical_compound medicine Humans Hernia Prospective Studies Postoperative Care Laparotomy Pain Postoperative business.industry Interleukins Growth factor Suture Techniques growth factor General Medicine Middle Aged Surgical Mesh medicine.disease Hernia repair Hernia Ventral interieukin mesh implantation Surgery Vascular endothelial growth factor Treatment Outcome Cytokine Surgical mesh chemistry Cytokines Female Surgery Inflammation Mediators Vascular endothelial growth factor production business Follow-Up Studies

description

Abstract Background The aim of this study was to evaluate changes in the production of some cytokines (interleukins [ILs]-6, -10, -1, and -1ra), vascular endothelial growth factor, and beta-fibroblast growth factor after polypropylene mesh implantation. Methods Twenty female patients were divided into 2 groups. In 1 group, hernia repair was performed with conventional sutures (CR), whereas in the other group polypropylene mesh (MR) was used. Growth factors and cytokines production was analyzed in wound drain fluids based on the amount produced during 24 hours. Results IL-1 increased substantially in MR patients on postoperative days 1 and 2. IL1-ra and IL-10 production was always significantly higher in CR patients. IL-6 production did not show any considerable difference between the 2 groups. Vascular endothelial growth factor production was significantly higher in the MR than the CR group at all time points, whereas beta-fibroblast growth factor production was higher in the MR than the CR group only on postoperative day 1. Comments Our data suggest that different surgical procedures induce various levels of inflammation and that implantation of prostheses significantly stimulates the inflammatory response.

year	journal	country	edition	language
2005-03-16

10.1016/j.amjsurg.2005.11.008 http://hdl.handle.net/10447/12440