6533b838fe1ef96bd12a3d29

RESEARCH PRODUCT

Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients

Paolo PorcuRoberto ChessaGiulia BivonaAngelo ZinelluCiriaco CarruSalvatore SotgiaMaria Antonietta CasuLuca Deiana

subject

Carotid Artery DiseasesMalemedicine.medical_specialtyArginineHomocysteinemedicine.medical_treatmentClinical BiochemistryCarotid endarterectomyArginineCohort Studiesrestenosischemistry.chemical_compoundRestenosisInternal medicinemedicineHumansCysteineHomocysteineAgedEndarterectomyEndarterectomy Carotidbusiness.industryBiochemistry (medical)General MedicineMiddle Agedmedicine.diseaseADMAStenosisSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicachemistryCardiologyRegression AnalysisFemaleMultiple linear regression analysisAsymmetric dimethylargininebusinesscarotid endarterectomy

description

Abstract Background: The aim of this work has been to study the association between plasma asymmetric dimethylarginine (ADMA) concentrations and carotid stenosis in a group of 64 patients undergoing carotid endarterectomy (CEA). Methods: Arginine, ADMA and symmetric dimethylarginine (SDMA) were measured using capillary electrophoresis with UV detection. An evaluation of plasma concentrations of total cysteine (tCys) and total homocysteine (tHcy) was also performed. Results: Pearson’s analysis show a positive correlation between ADMA and carotid stenosis (r=0.37, p=0.003), which is also confirmed after stepwise multiple linear regression analysis. ADMA plasma concentrations were significantly associated with tHcy (r=0.40, p=0.001) and to a lesser extent, even if not significantly, with tCys (r=0.23, p=0.07). Conclusions: Our data suggest that plasma ADMA is involved in carotid narrowing after CEA intervention. This suggests that this molecule may have an important role in the events that lead to stenosis.

yearjournalcountryeditionlanguage
2011-02-03cclm
https://doi.org/10.1515/cclm.2011.121