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RESEARCH PRODUCT
Non-specific Hyperreactivity to Pharmacological Stimuli in Tracheal and Lung Parenchymal Strips of Actively Sensitized Guinea-pigs
Miguel PerpiñáCelia SanzJuan V. EspluguesE. MorcilloE. MorcilloJulio CortijoJ. L. OrtizC. F. IriarteC. F. IriarteBenjamín Sarriásubject
Malemedicine.medical_specialtyGuinea PigsPharmaceutical ScienceIn Vitro TechniquesMuscle Smooth VascularPotassium ChlorideGuinea pigCalcium Chloridechemistry.chemical_compoundInternal medicineParenchymamedicineAnimalsRespiratory systemLungPharmacologyLungChemistrySerum Albumin BovineAcetylcholineTracheamedicine.anatomical_structureEndocrinologyAnesthesiaImmunohistochemistryHistamineAcetylcholineHistamineMuscle ContractionRespiratory tractmedicine.drugdescription
Abstract The responsiveness of tracheal and lung parenchymal strips isolated from actively sensitized guinea-pigs to CaCl2 (in K+-depolarized tissue), KCl, acetylcholine and histamine was compared with that of strips from unsensitized animals. The concentration-response curves to the mentioned agonists exhibited, in the sensitized group, a left upward displacement (greater maximal effect, lesser effective concentration 50% and a steeper slope) compared with those obtained in the unsensitized group. These results indicate the existence of a non-specific increase in responsiveness in the airway smooth muscle from sensitized animals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-05-01 | Journal of Pharmacy and Pharmacology |