6533b838fe1ef96bd12a3daa
RESEARCH PRODUCT
Phytochemical profile of three Ballota species essential oils and evaluation of the effects on human cancer cells
Mariangela MarrelliDaniela RiganoFelice SenatoreFilomena ConfortiMaurizio BrunoCarmen FormisanoFrancesco Menichinisubject
antiproliferative activitySesquiterpeneAntioxidantDPPHmedicine.medical_treatmentBallota undulataHep G2 CellPlant Science01 natural sciencesBiochemistryAntioxidantsessential oilGas Chromatography-Mass Spectrometrylaw.inventionAnalytical Chemistrychemistry.chemical_compoundbreast cancerMCF-7 CelllawsesquiterpenesmedicineBallota nigraOils VolatileHumansIC50Essential oilBallota speciebiologyTraditional medicine010405 organic chemistryOrganic ChemistryHep G2 Cellshepatomabiology.organism_classificationBallotaAntineoplastic Agents Phytogenic0104 chemical sciences010404 medicinal & biomolecular chemistryBiochemistrychemistryPhytochemicalMCF-7 CellsBallotaAntioxidantHumandescription
Three Ballota species, Ballota undulata, Ballota saxatilis and Ballota nigra ssp. foetida, were investigated for their cytotoxicity against two human cancer cells, hepatoma HepG2 cell line and breast cancer MCF-7 cell line, and for their antioxidant activity. The chemical composition of essential oils was studied by GC and GC–MS. Sesquiterpenes were the main constituents. The most antiproliferative essential oil against HepG2 cells was B. undulata with a percentage of inhibition of 81.36 ± 3.54 at a concentration of 100 μg/mL, while against MCF-7 cells essential oil from B. saxatilis was the most active with a percentage of inhibition of 24.18 ± 1.13 at a concentration of 100 μg/mL. The antioxidant activity was investigated by DPPH test for all the oils. B. undulata showed the highest antiradical effect, with IC50 value of 529.7 ± 37.4 μg/mL.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |