6533b838fe1ef96bd12a3dca
RESEARCH PRODUCT
The hemagglutinin of Staphylococcus saprophyticus is a major adhesin for uroepithelial cells.
U. Wengler-beckerS. G. GatermannH.-g. W. Meyersubject
StaphylococcusImmunologyBiologymedicine.disease_causeMicrobiologyBacterial AdhesionEpitheliumMicrobiologymedicineAnimalsHumansAntiserumchemistry.chemical_classificationStaphylococcus saprophyticusSheepBinding proteinErythrocyte MembraneHemagglutininbiology.organism_classificationFibronectinsBacterial adhesinInfectious DiseasesHemagglutininschemistryParasitologyUreterGlycoproteinStaphylococcusBacteriaResearch Articledescription
The 160-kDa hemagglutinin of Staphylococcus saprophyticus also serves as a fibronectin-binding protein, and the two activities may be present on different parts of the molecule. Bacteria expressing the 160-kDa hemagglutinin bound in large numbers to histological sections of human ureters, whereas nonhemagglutinating bacteria did not bind. Binding was decreased by an antiserum to the 160-kDa protein and by a preparation of sheep erythrocyte membranes. Fibronectin had no effect. We therefore conclude that binding of S. saprophyticus to uroepithelial cells is mediated by the hemagglutinating activity of the 160-kDa surface protein.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-09-01 | Infection and immunity |