6533b838fe1ef96bd12a3e2a

RESEARCH PRODUCT

Hepatic extraction of isosorbide dinitrate in cardiac patients

R.a. MorrisonR.a. MorrisonHo-leung FungHo-leung FungD HöhmannD HöhmannU.-w WiegandU.-w WiegandE JähnchenE JähnchenKasper WKasper WMeinertz TMeinertz T

subject

Malemedicine.medical_specialtyMetaboliteBiological AvailabilityCoronary DiseaseIsosorbide DinitratePharmacologylaw.inventionchemistry.chemical_compoundlawInternal medicineHepatic extractionmedicineHumansInfusions ParenteralPharmacology (medical)In patientPharmacologyClinical pharmacologybusiness.industryVenous bloodMiddle AgedBioavailabilityKineticsEndocrinologyLiverchemistryTime courseIsosorbide dinitratebusinessmedicine.drug

description

Hepatic extraction of organic nitrates, including that of isosorbide dinitrate (ISDN), has been thought to be nearly complete in man but has never been directly measured. We examined the time course of plasma ISDN and metabolite concentrations in arterial and hepatic venous blood in four cardiac patients receiving an intravenous ISDN infusion. Apparent hepatic extraction of ISDN was high (90%) at the beginning of infusion but fell to about 44% 1 hr after termination of infusion. The decrease in ISDN concentration gradient across the liver correlates with an increase in plasma isosorbide-5-mononitrate concentration, but a cause-and-effect relationship resulting from metabolite inhibition cannot be established. The time-averaged hepatic extraction of ISDN, at about 70%, agreed with its oral bioavailability in patients. Clinical Pharmacology and Therapeutics (1983) 34, 724–731; doi:10.1038/clpt.1983.241

yearjournalcountryeditionlanguage
1983-12-01Clinical Pharmacology and Therapeutics
https://doi.org/10.1038/clpt.1983.241