6533b838fe1ef96bd12a3e7f
RESEARCH PRODUCT
Two fungal lanostane derivatives as phospholipase A2 inhibitors.
José-luis RíosMaria Jose JustMaría-carmen RecioRosa-maría GinerM J CuéllaSalvador Máñezsubject
StereochemistryGanodermaCarboxylic acidPharmaceutical SciencePharmacognosyLanostanePhospholipases AAnalytical ChemistryPolyporaceaechemistry.chemical_compoundPhospholipase A2Oxygen ConsumptionTriterpeneDrug DiscoveryEnzyme InhibitorsPharmacologychemistry.chemical_classificationbiologyOrganic Chemistrybiology.organism_classificationTriterpenesPhospholipases A2Complementary and alternative medicinechemistryBiochemistryEnzyme inhibitorSnake venombiology.proteinMolecular MedicinePolarographySnake Venomsdescription
The hydroalcoholic extract of Poria cocos and two lanostane derivatives isolated from it, pachymic acid (1) and dehydrotumulosic acid (2), were active as inhibitors of phospholipase A2 from snake venom when a polarographic method was used. Dehydrotumulosic acid exhibited an IC50 of 0.845 mM. These two compounds are structurally related to certain triterpenoids from Ganoderma and Schinus that have previously been described as competitive inhibitors of phospholipase A2. These comprise a new group of natural potential antiinflammatory agents due to their interaction with that enzyme.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-10-01 | Journal of natural products |