Studies of gabaergic system-targeted substances in a rat model of sporadic Alzheimer’s disease

6533b838fe1ef96bd12a40ef

RESEARCH PRODUCT

Studies of gabaergic system-targeted substances in a rat model of sporadic Alzheimer’s disease

Vladimirs Piļipenko

subject

Pharmacology Medicine Farmakoloģija Medicīna

description

Pirmo reizi ir atklāts, ka GABA receptoru agonisti sporādiskās Alcheimera slimības modeļdzīvniekiem uzlabo telpiskās atmiņas procesus, normalizē patoloģiskās izmaiņas smadzeņu garozas un hipokampa audu proteīnu ekspresijā, kas atbild par neiroiekaisumu, acetilholīna šķelšanu, GABA sintēzi, sinaptisko plasticitāti. Gammapirons nesaistās ar GABA receptoriem, bet darbojās līdzīgi in vivo un ex vivo eksperimentos, bez tam in vitro uzrādot arī mitohondriju funkciju regulējošās īpašības. Iegūtie dati liecina par pētāmo vielu alostēriskās regulācijas mehānismiem un lietošanas perspektīvam agrīno neirodeģeneratīvo simptomu apstādināšanā, slimības attīstības aizkāvēšanā. Pētamās vielas var kalpot kā kandidātmolekulas jaunu pretdemences preparātu dizainā. Atslēgvārdi: GABA, streptozocīns, muscimols, baklofēns, diazepāms, gammapirons

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/49043

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