Melleņu ģints ogu izspiedu ekstraktu neiroprotektīvie efekti SH-SY5Y šūnu modelī

6533b838fe1ef96bd12a40f4

RESEARCH PRODUCT

Melleņu ģints ogu izspiedu ekstraktu neiroprotektīvie efekti SH-SY5Y šūnu modelī

subject

antioksidanti SH-SY5Y šūnu līnija Vaccinium spp. ogu izspiedu ekstrakti neiroprotekcija Farmācija acetilholīnesterāze

description

Mūsdienās pieaug interese par Vaccinium spp. ogu izspiedām, kā par potenciālu veselībai nozīmīgu ar fitoķīmiskām vielām bagātu avotu. Neirodeģenerācija ir patoloģisku procesu kopums, kas izraisa neironu nāvi, tāpēc tā novēršanai tiek meklēti neiroprotektīvi savienojumi. Darba mērķis ir pētīt piecu Vaccinium spp. ogu izspiedu ekstraktu acetilholīnesterāzes inhibīciju bezšūnu un SH-SY5Y šūnu modeļos un šūnu izdzīvošanas stimulāciju ar terciālā butilhidroksiperoksīda izraisītā oksidatīvā stresa apstākļos. Visi ogu ekstrakti inhibēja acetilholīnesterāzes aktivitāti, kā arī uzlaboja SH-SY5Y šūnu dzīvotspēju oksidatīvā stresa modelī. Augstāka acetilholīnesterāzes inhibīcija bija novērojama SH-SY5Y šūnu modelī. Secinājām, ka Vaccinium spp. ogu izspiedu ekstraktiem ir neiroprotektīvas īpašības in vitro.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59783

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