6533b838fe1ef96bd12a4607
RESEARCH PRODUCT
Triterpene Saponins from Cyclamen persicum
Marie Aleth Lacaille-duboisAnne Claire Mitaine-offerGhezala Mihci-gaidiOlivier DuchampDavid PertuitJean François MirjoletTomofumi Miyamotosubject
Magnetic Resonance SpectroscopyStereochemistryChemical structureSaponinPlant ScienceInhibitory Concentration 50TriterpeneCell Line TumorDrug DiscoveryHumansCyclamenCytotoxicityMedicinal plantsCyclamen persicumPharmacologychemistry.chemical_classificationMolecular StructurebiologyGlycosideGeneral MedicineSaponinsbiology.organism_classificationTriterpenesHuman colon cancerComplementary and alternative medicinechemistrydescription
A new triterpene saponin 3- O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl-16α-hydroxy-13β,28-epoxy-oleanan-30-al (1), along with four known triterpene glycosides (2-5) were isolated from Cyclamen persicum. Their structures were characterized by a combination of 1D- and 2D-NMR (1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and MS spectrocopic data. The cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-26 | Natural Product Communications |