6533b838fe1ef96bd12a4639
RESEARCH PRODUCT
Breast cancer cells exhibit selective modulation induced by different collagen substrates.
Patrizia CancemiLuigi Minafra 1*Nadia Ninfa AlbaneseGianluca Di CaraIda Pucci-minafraMaria Rita Marabetisubject
ProteomicsPathologymedicine.medical_specialtyConnective tissueBreast NeoplasmsMatrix (biology)ProteomicsBiochemistryBreast cancerRheumatologymedicineAnimalsHumansOrthopedics and Sports MedicineNeoplasm InvasivenessNeoplasm MetastasisSettore BIO/06 - Anatomia Comparata E Citologiaskin and connective tissue diseasesCollagen substrateMolecular BiologyCollagen Substrate Breast Cancer ProteomicsChemistryCell Biologymedicine.diseaseExtracellular MatrixSelective modulationSettore BIO/18 - Geneticamedicine.anatomical_structureCancer researchBasal laminaBreast cancer cellsCollagenStromal Cellsdescription
During the invasive phase of malignant tumors, neoplastic cells break into the basal lamina and enter in contact with the underlying connective tissue, which concurrently undergoes extensive modifications. The aim of our present minireview is to focus the changes in the collagenous matrix occurring during breast cancer progression and to explore the possible effects of different collagen substrates on breast cancer cell behavior and proteomic modulation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-07-29 |