6533b838fe1ef96bd12a464a
RESEARCH PRODUCT
Physical activity and fat-free mass during growth and in later life.
Klaas R WesterterpYosuke YamadaHiroyuki SagayamaPhilip N AinslieLene F AndersenLiam J AndersonLenore ArabIssaad BaddouKweku Bedu-addoEllen E BlaakStephane BlancAlberto G BonomiCarlijn V C BoutenPascal BovetMaciej S. BuchowskiNancy F ButteStefan G J A CampsGraeme L CloseJamie A CooperSai K DasRichard CooperLara R. DugasUlf EkelundSonja EntringerTerrence ForresterBarry W FudgeAnnelies H GorisMichael GurvenCatherine HamblyAsmaa El HamdouchiMarije B HoosSumei HuNoorjehan JoonasAnnemiek M JoosenPeter KatzmarzykKitty P KempenMisaka KimuraWilliam E KrausRobert F KushnerEstelle V LambertWilliam R LeonardNader LessanCorby K MartinAnine C MedinErwin P MeijerJames C MorehenJames P MortonMarian L NeuhouserTheresa A NicklasRobert M OjiamboKirsi H PietiläinenYannis P PitsiladisJacob Plange-rhuleGuy PlasquiRoss L PrenticeRoberto A RabinovichSusan B. RacetteDavid A RaichlenEric RavussinRebecca M ReynoldsSusan B RobertsAlbertine J SchuitAnders SjödinEric SticeSamuel S UrlacherGiulio ValentiLudo M Van EttenEdgar A Van MilJonathan C K WellsGeorge WilsonBrian M WoodJack YanovskiTsukasa YoshidaXueying ZhangAlexia J. Murphy-alfordCornelia U LoechlAmy H LukeHerman PontzerJennifer RoodDale A SchoellerWilliam W WongJohn R SpeakmanStefan BranthLisa H ColbertNiels C De BruinAlice E DutmanSölve ElmståhlMikael FogelholmTamara HarrisRik HeijligenbergHans U JorgensenChristel L LarssonElisabet M RothenbergMargaret MccloskeyGerwin A MeijerDaphne L PannemansSabine SchulzRita Van Den Berg-emonsWim G Van GemertW WilhelmineVenne Verboeket-van DeJeanine A VerbuntRenaat M PhilippaertsAmy SubarMinna TanskanenRicardo UauyErica J Velthuis-te Wieriksubject
Adipose Tissue/metabolismMaleAgingIMPACTMedicine (miscellaneous)Medical and Health SciencesLONGITUDINAL CHANGESRC12000302 clinical medicineEngineeringenergy expenditureFaculty of Science80 and overMedicineWATER030212 general & internal medicineChildInternational Atomic Energy Agency Doubly Labeled Water database groupAged 80 and overNutrition and DieteticsMiddle Aged3142 Public health care science environmental and occupational healthEditorialAdipose TissueChild PreschoolFemalephysical activity levelPeak bone massAdultAdolescentPhysical activityBONE MASS030209 endocrinology & metabolismDoubly labeled waterFat massVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 81103 medical and health sciencesYoung AdultAnimal scienceTotal energy expenditureFat free massClinical ResearchBENEFITSHumansResting energy expenditure/dk/atira/pure/core/keywords/TheFacultyOfSciencePreschoolExerciseNutritionAgedbody compositionNutrition & DieteticsAdipose Tissue/metabolism; Adolescent; Adult; Aged; Aged 80 and over; Body Composition; Child; Child Preschool; Cross-Sectional Studies; Energy Metabolism; Exercise; Female; Humans; Male; Middle Aged; Young Adult; age; body composition; doubly labeled water; energy expenditure; physical activity levelbusiness.industryPreventionPhysical activity leveldoubly labeled water3141 Health care scienceCross-Sectional StudiesageLEAN BODY-MASSYOUNGWEIGHTbusinessEnergy Metabolismhuman activitiesdescription
ABSTRACT Background Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives A study is presented of the association between FFM and physical activity in relation to age. Methods In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3–96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution. Results PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM–adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: −0.2, 1.7 kg) and 1.0 kg (95% CI: −0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively. Conclusions If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-08 |