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RESEARCH PRODUCT

Correlation between superoxide dismutase, glutathione peroxidase and catalase in isolated rat hepatocytes during fetal development

G. RotilioIrene MavelliLuciana DiniA. SpinediF. AutuoriMaria Rosa Ciriolo

subject

AgingGPX3BiophysicsGestational AgeAntioxidative enzymeSettore BIO/09BiochemistryGPX5GPX6Superoxide dismutaseFetusPregnancyAnimalsMolecular Biologychemistry.chemical_classificationGlutathione PeroxidaseFetusbiologySuperoxide DismutaseChemistryGlutathione peroxidaseRats Inbred StrainsCell BiologyCatalaseRatsAnimals NewbornLiverPeroxidasesBiochemistryCatalasebiology.proteinFemale

description

Abstract Superoxide dismutase, glutathione peroxidase and catalase activities were determined in isolated fetal rat hepatocytes of various ages and compared with the values of neonatal and adult cells. The developmental pattern of superoxide dismutase and glutathione peroxidase were very similar with a low constant activity in the fetal cells and a postnatal burst. On the contrary catalase begins to increase already since the 18th day of the fetal life. The results suggest a functional correlation of superoxide dismutase and glutathione peroxidase in the antioxidative enzyme defense of liver cells.

yearjournalcountryeditionlanguage
1981-01-01Biochemical and Biophysical Research Communications
https://doi.org/10.1016/0006-291x(81)91624-7