6533b838fe1ef96bd12a4cbe
RESEARCH PRODUCT
Experimental investigations on a model of cryogenic edema.
G. GambardellaG. GermanaE. CiriacoDomenico IacopinoU. MugliaF. Tomasellosubject
Body WaterSettore MED/27 - NeurochirurgiaBlood-Brain BarrierReplantationFreezingAnimalsBrain EdemaBrain Edema; Blood-Brain Barrier; Body Water; CraniotomyRabbitsCerebral edema experimental modelCraniotomySurgical Flapsdescription
The role of mechanisms underlying formation and progression of vasogenic brain edema is investigated. On this purpose, cerebral edema was produced by cortical freezing in two different brain situations in rabbits (with or without replacement of bone flap). BBB (Blood-Brain Barrier) breakdown was evaluated by observation of Evans blue extravation, while a histopathological evaluation was carried out by light and transmission electron microscopy. Water content of brain tissue was determined by the wet/dry weight ratio method. Comparison of extension and intensity of cerebral edema between these two groups of animals shows a statistically significant difference: there was evidence of higher water content in the animals undergone replacement of bone flap. The Authors emphasize the importance of tissue pressure gradients in determining diffusion of cerebral edema.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-07-01 | Journal of neurosurgical sciences |