6533b838fe1ef96bd12a4da5

RESEARCH PRODUCT

Phytochemical study of plant species : Phytolacca rugosa, P. icosandra, Cestrum ruizteranianum et Ganophyllum giganteum

subject

description

Phytochemical analysis of the MeOH/H2O (7:3) of the fruits of Phytolacca rugosa, P. icosandra and Cestrum ruizteranianum, as well as the barks of Ganophyllum giganteum, leaded to the isolation and structural characterization of twenty three (1-23) compounds. From P. rugosa, four (1-4) known triterpenoidal saponins belonging to the serjanic acid series were obtained, all saponins are reported for the first time for P. rugosa. P. icosandra was studied and eight compounds were isolated, two triterpenic acids [spergulagenic acid (5) and epiacetylaleurytolic acid (6)], two lignanes (7) and (8) [8, reported for the first time in Phytolaccaceae], a mixture of steroidal glycosides (9) and (9a), two triterpenoidal saponins (10 - 11) and a peltoginoid-type compound (12). Analysis of C. ruizteranianum leaded to the isolation of a triterpene mixture [oleanolic and ursolic acids (13)] and seven known (14-20) spyrostane (14, 15) and furostane-type (16-20) saponins. All saponins are reported for the firs time in Cestrum genus. Finally, from the bark of G. giganteum, three saponins (21-23) belonging to the zanhic acid series were obtained. Compounds determined as: 3-O-(-D-2-acetoxy-glucopyranosyl) 28-O--D-glucopyranosyl-serjánic acid (10) ; 9,10-metylendioxy, 5-metoxy-peltoginane (12); 28-O-{-D-4-O-acetylfucopyranosyl [(12)--L-rhamno-pyranosyl] (13)--D-xylo-pyranosyl}-3-O--D-glucoronopyranosyl-zanhic acid (21); 28-O-{-D-4-O-acetyl-fucopyranosyl [(12)--D-glucoronopyranosyl] (13)--D-xylopyranosyl}-3-O--L-rhamnopyranosyl-zanhic acid (22) and 28-O-{-D-4-O-acetylglucopyranosyl [(12)--D-glucoronopyranosyl] (13)--D-xylopy-ranosyl (12)--D-glucopyrano-syl}-3-O--L-rhamnopyranosyl-zanhic acid (23), are described in this study as new natural products.