6533b838fe1ef96bd12a4fe1
RESEARCH PRODUCT
Studies in organic mass spectrometry. IV. Electron impact induced fragmentation of 2-substituted 3-(5-isoxazolyl)-4(3H)-quinazolinones of pharmaceutical interest
Leopoldo CerauloGiuseppe DaidoneM. L. BajardiSalvatore Plesciasubject
chemistry.chemical_compoundFragmentation (mass spectrometry)Bicyclic moleculechemistryOrganic ChemistryMass spectrumOrganic chemistryIsoxazoleMass spectrometryAcetonitrileMedicinal chemistryElectron ionizationIondescription
The fragmentation under electron impact of thirteen 2-substituted-3-(5-isoxazolyl)-4(3H)-quinazolinones has been investigated with the aid of metastable ion detection and high resolution measurements. Molecular ions are always abundant and the main primary fragmentation route involves acetonitrile elimination through isoxazole ring opening. The other common processes, particularly those leading to the abundant [R-C8H4N2]+ ion (b or b'), as well as those due to the nature of the 2-substituent are reported and discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1984-07-01 | Journal of Heterocyclic Chemistry |