6533b838fe1ef96bd12a5129
RESEARCH PRODUCT
The inhibitory neural circuitry as target of antiepileptic drugs.
Hartmut LüddensIngo Böhmesubject
GABA Plasma Membrane Transport ProteinsGABA Plasma Membrane Transport ProteinsOrganic Anion TransportersDrug actionPharmacologyNeurotransmissionBiologyInhibitory postsynaptic potentialBiochemistrySynaptic TransmissionGABA AntagonistsEpilepsyDrug DiscoverymedicineAnimalsHumansGlycine receptorgamma-Aminobutyric AcidPharmacologyEpilepsyOrganic ChemistryMembrane ProteinsMembrane Transport Proteinsmedicine.diseaseReceptors GABA-AMechanism of actionReceptors GABA-BMolecular MedicineGABAergicAnticonvulsantsmedicine.symptomCarrier Proteinsdescription
Impairments and defects in the inhibitory neurotransmission in the CNS can contribute to various seizure disorders, i.e., gamma-aminobutyric acid (GABA) and glycine as the main inhibitory neurotransmitters in the brain play a crucial role in some forms of epilepsy. Recent advances in deciphering the molecular basis of the GABAergic and glycinergic systems has been achieved by means of cloning techniques and gene targeting strategies in animals, contributing to the understanding of drug action. As well, several anticonvulsive substances emerged which target key molecules of the inhibitory systems. Employment of recombinant expression systems, including, but not restricted to the inhibitory circuitry, will further facilitate drug screening and rational approaches to design novel specific antiepileptic drugs, which act highly efficiently to prevent or reduce generation and spread of seizures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-09-01 | Current medicinal chemistry |