Cytotoxic activity of the histone deacetylase 3-Selective inhibitor Pojamide on MDA-MB-231 triple-negative breast cancer cells

6533b838fe1ef96bd12a5134

RESEARCH PRODUCT

Cytotoxic activity of the histone deacetylase 3-Selective inhibitor Pojamide on MDA-MB-231 triple-negative breast cancer cells

Fabio Caradonna Supojjanee Sansook Claudio Luparello Ilenia Cruciata Storm Hassell-hart John Spencer Dalia Maria Lucia Asaro

subject

0301 basic medicine QD0901 Triple Negative Breast Neoplasms lcsh:Chemistry 0302 clinical medicine breast cancer cell mitochondrial transmembrane potential Cytotoxic T cell QD Settore BIO/06 - Anatomia Comparata E Citologia lcsh:QH301-705.5 Spectroscopy Triple-negative breast cancer reactive oxygen species Cell Death Chemistry Histone deacetylase inhibitor Q apoptosis General Medicine Cell cycle 3. Good health Computer Science Applications 030220 oncology & carcinogenesis Female cell cycle Programmed cell death autophagy medicine.drug_class Cell Survival Catalysis Article Histone Deacetylases Inorganic Chemistry 03 medical and health sciences Cell Line Tumor medicine Biomarkers Tumor Humans Viability assay Physical and Theoretical Chemistry Molecular Biology histone deacetylase inhibitor cell viability Organic Chemistry Autophagy apoptosi Matrix Metalloproteinases Histone Deacetylase Inhibitors Settore BIO/18 - Genetica 030104 developmental biology lcsh:Biology (General)lcsh:QD1-999 Apoptosis Cancer research QD0146 breast cancer cells

description

We examined the effects of the ferrocene-based histone deacetylase-3 inhibitor Pojamide (N1-(2-aminophenyl)-N8-ferrocenyloctanediamide) and its two derivatives N1-(2-aminophenyl)-N6-ferrocenyladipamide and N1-(2-aminophenyl)-N8-ferroceniumoctanediamide tetrafluoroborate on triple-negative MDA-MB-231 breast cancer cells. Viability/growth assays indicated that only the first two compounds at 70 &mu

year	journal	country	edition	language
2019-02-13

10.3390/ijms20040804

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